Парацетамол сегодня есть практически в каждой домашней аптечке. Этот медицинский препарат активно используется в качестве противовоспалительного, обезболивающего и жаропонижающего средства как для взрослых, так и детей. Однако, неправильная дозировка и несоблюдения правил приема, могут привести к тому, что это универсальное лекарство превратится в настоящий яд, стремительно уничтожающий весь организм. Чтобы избежать этого, стоит больше узнать о том, какая смертельная доза парацетамола, как распознать отравление и оказать экстренную медицинскую помощь.
Причины передозировки парацетамолом
Самой основной причиной, по которой прием парацетамола приводит к передозировке, является превышение допустимого его количества как при разовом приеме, так и на протяжении всего курса лечения.
Среди других причин отравления стоит выделить:
- Недостаточную медицинскую грамотность и невнимательное прочтение инструкции. Разные по названию средства могут иметь полностью аналогичный состав, основой которого выступает парацетамол. И получается, лекарства выпил столько, сколько таблеток парацетамола нужно выпить по инструкции. Чтобы умереть, достаточно просто повысить допустимую дозу до 10 таблеток – это принятые за день несколько видов жаропонижающих, активным компонентом которых является парацетамол.
- Несовместимость жаропонижающего с отдельными видами лекарственных препаратов. Речь идет об антигистаминных средствах, глюкокортикостероидах, этакриновой кислоте, фенобарбитале.
- Употребление в процессе лечения алкоголя. Даже незначительная концентрация лекарства в сочетании со спиртными напитками приводит к тяжелому токсическому поражению печени.
Важно! Допустимая разовая доза парацетамола не должна превышать 1 г. В течение дня взрослые и подростки от 12 лет могут использовать 4 г. Общий рекомендованный курс лечения не должен быть более 5 дней.
Использование парацетамола одноразово в количестве 20 г или 40 г на протяжении суток, является смертельной дозой. Препаратом в 10 таблеток (или 4-5 г) можно отравится. При превышении дозировки до 7,5-10 г начинает формироваться токсическое поражение тяжелой степени.
Стадии и симптомы передозировки парацетамолом
Симптоматика развития отравления от приема дозы парацетамола будет напрямую зависеть от его дозировки, продолжительности воздействия на организм и других факторов. Условно, передозировка по степени сложности и набору симптомов делится на 4 основные стадии:
- Выявить первую стадию отравления парацетамолом можно только при помощи проведения анамнеза. Состояние не является критическим, поражение печени не происходит и, как следствие, выраженных симптомов у пациента нет. Может только появится тошнота, рвота, общее недомогание и плохой аппетит.
- На второй стадии происходит поражение печени. Наступает оно по истечению суток после острого отравления. Определяется как по характерной симптоматики гепатоксического воздействия, так и анализу крови — уровень аспартатаминотрансферазы превышает 1000 мЕ/л.
- Острый некроз печения – это третья стадия. Ее наступление происходит при несвоевременно начатом лечении или очень высокой одноразовой дозировке. При таких ситуациях наблюдается пик гепатотоксичности парацетамола. Из-за концентрации в организме билирубина и молочной кислоты критически страдает печень и другие органы, их функционирование. Дальше происходит ацидоз.
- На четвертой стадии при своевременном и эффективном лечении происходит восстановление организма. Печень и другие системы снова начинают возвращаться к своей нормальной работе. Длиться такой период может от 2-х недель и до нескольких месяцев.
В особо тяжелых случаях у пациентов развивается сепсис, отек головного мозга, генерализированные кровотечения, происходит комплексный отказ функционирования отдельных систем. Это все неизбежно приводит к летальному исходу.
Первая помощь при передозировке
Если возникло подозрение на развитие отравления или выпито чрезмерное количество парацетамола в мг на 1 кг веса, но такая дозировка недопустима инструкцией, то стоит незамедлительно обратиться за врачебной помощью. В особо тяжелых случаях просто необходима следующая первая помощь:
- Оперативное промывание желудка. Оно поможет вывести из желудка еще не попавший в кровь препарат. Для этого выпивается литр воды и провоцируется рвота.
- Прием сорбентов. Это может быть любое средство из домашней аптечки – атоксил, сорбекс, энтеросгель или обыкновенный активированный уголь.
- Питьевой режим. Чтобы почки как можно быстрее вывели лекарство из организма, необходимо выпивать большое количество жидкости. Для данных целей подойдет минеральная или обыкновенная вода.
Важно! Даже если состояние улучшиться и исчезнет ряд симптомов, от врачебной помощи отказываться категорически не стоит. Определить степень отравления и причиненный организму вред сможет только клинический анализ крови.
Лечение передозировки
Первичное лечение отравлений препаратом включает в себя:
- снижение интоксикации посредством капельниц со специальным раствором;
- нормализация функционирования сердца и дыхания при помощи медикаментов;
- временное использование кислородной маски.
Если пациентом была принята смертельная доза парацетамола в таблетках, то он незамедлительно направляется в интенсивную терапию. Как только жизненные показатели будут стабилизированы, больной помещается в токсикологическое отделение для продолжения лечения с целью восстановления работы организма.
Последствия передозировки парацетамолом
Отравление парацетамолом может приводить к серьезным проблемам в работе всего организма. Это могут быть кратковременные последствия, длящиеся до 5 дней, так и долгосрочные – более двух месяцев.
Основным и самым типичным последствием от передозировки является острая почечная недостаточность, которая влечет за собой целый ряд осложнений, вплоть до летального исхода.
Особенности передозировки у детей
Пожилые люди и дети относятся к особой группе пациентов. Разовая доза жаропонижающего для них составляет меньшее количество, чем для взрослого здорового человека. Поэтому и передозировка наступает при меньшем его поступлении в организм.
Опасной для ребенка является доза в 150 мг на кг веса, но такая форма приема может только в 4% случаев проявляться признаками печеночной недостаточно.
Парацетамол, как и другое лекарственное средство, должен приниматься в строго определенных дозах. Только при соблюдении всех правил препарат поможет справиться с болью и высокой температурой, а не стать причиной серьезного отравления.
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